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Educational pricing information only — not medical advice. Compounded semaglutide and tirzepatide are not FDA-approved finished drug products and are not reviewed by the FDA for safety, effectiveness, or quality. Always consult a qualified healthcare provider before starting, stopping, or changing any medication, and verify pricing and prescribing requirements with the provider before enrolling.
Affiliate & partnership disclosure. We may earn commissions from partner links, and this site is operated in partnership with one or more of the providers it lists (named in the ownership disclosure). Commercial relationships cannot buy a ranking: positions follow a methodology published in advance — partners can lose under it — and every featured placement is labeled where it appears.
Written by Kim Callender, NP, FNP-BC·Reviewed by Jonathan Snipes, MD·Published July 12, 2026·Last reviewed September 4, 2026·Prices verified September 4, 2026·Methodology v1.0

The GLP-1 pathway that costs $25 a month

Everyone comparing cash prices should spend twenty minutes on this first. Most do not.

The short version

If your plan covers Zepbound or Wegovy, a manufacturer savings card can bring it to roughly $25. Nothing on the cash market competes.

The analysis

Do this before anything elseCheck your insurance before you compare any cash price. If your plan covers Zepbound or Wegovy, the manufacturer savings card can bring your cost to roughly $25/month — which beats every cash option on this site by an order of magnitude, for an FDA-approved product.

Coverage is most common through employer-sponsored commercial plans. Zepbound is excluded from Medicare Part D for weight loss and from most state Medicaid programmes. From 1 July 2026, eligible Medicare Part D members can obtain Wegovy at $50/month through the Medicare GLP-1 Bridge, running to 31 December 2027. Expect prior-authorisation paperwork: typically a BMI of 30+, or 27+ with a weight-related condition.

PlushCare ($19.99/month), Found and Mochi will handle that paperwork for you. If you have coverage, that is worth more than any cash discount.
Insurance-coordinated pathways — cheapest of all, if you have coverage
PathwayCostWhat it doesStatus
Brand + commercial coverage + savings cardas low as $25/moZepbound or Wegovy when the plan covers it. Beats every cash path here.Verified
Medicare GLP-1 Bridge (Wegovy)$50/moEligible Part D members, 1 Jul 2026 - 31 Dec 2027. Prior auth required.Verified
PlushCare$19.99/mo membership + copayCheapest membership in the category. Prior-auth support. $129 initial visit.Provider Reported
Found (insurance option)$99/mo (12-mo) to $199/mo + ~$30/visitFree insurance check built in.Provider Reported
Mochi Health$79/mo membership + copayCoordinates insurance for brand medication.Provider Reported

What a commitment actually costs you

Before you commit to a long planA committed plan lowers the monthly figure and raises the risk. Before you sign one, ask what happens if you stop early — because a meaningful number of people do. Roughly one in five patients discontinues a GLP-1 within the first few months, most often because of gastrointestinal side effects. Others stop because insurance unexpectedly approves a brand product, or because they reach a goal weight, or because their circumstances change.

Providers differ enormously in what happens then. Some refund the unused portion. Some convert you to the month-to-month rate and bill the difference for months already taken. Some refund nothing. This is the single question people most often forget to ask, and it is the one most likely to cost them money.

Dose escalation: the risk the headline price hides

The question that matters more than the headline priceAsk what you will pay at your target maintenance dose, not at the starting dose. This is the difference between a programme that quotes a flat rate at every dose and one that escalates: MEDVi's compounded tirzepatide reaches $499/month at 10-15mg against a $399 headline; Shed's injectables rise with dose; Oak escalates $50-$75 per step. Over a year, on a full titration, the gap between a flat-rate programme and an escalating one can exceed $3,000 — far more than any difference in the advertised starting price.
Does the price rise with your dose?
ProviderPrice at higher dosesRisk
NexLifeSame at every covered doseNone — flat rate
Mochi HealthSame at all dosesNone
Enhance.MDSame at all dosesNone
EdenSame at all doses (compounded)None on compounded
TrimRxFlat ongoing rateNone
Oak LongevityFlat across dosagesNone
ShedIncreases at higher dosesMaterial — model at maintenance
MEDVi$399 → $499 at 10-15mgMaterial — $1,200/yr swing
LillyDirect (brand)$299 → $449; $699 if you miss the 45-day refillMaterial — set a reminder

The insurance pathway

Do this before anything elseCheck your insurance before you compare any cash price. If your plan covers Zepbound or Wegovy, the manufacturer savings card can bring your cost to roughly $25/month — which beats every cash option on this site by an order of magnitude, for an FDA-approved product.

Coverage is most common through employer-sponsored commercial plans. Zepbound is excluded from Medicare Part D for weight loss and from most state Medicaid programmes. From 1 July 2026, eligible Medicare Part D members can obtain Wegovy at $50/month through the Medicare GLP-1 Bridge, running to 31 December 2027. Expect prior-authorisation paperwork: typically a BMI of 30+, or 27+ with a weight-related condition.

PlushCare ($19.99/month), Found and Mochi will handle that paperwork for you. If you have coverage, that is worth more than any cash discount.

Dose caps: the other thing a low price can hide

A capped dose is not a discountWatch for dose caps as well as dose escalation. Noom Med's $199 compounded semaglutide programme is capped at 0.6mg — the STEP trials that established semaglutide's efficacy used 2.4mg. A capped programme is not a cheaper version of the same treatment; it is a lower-dose treatment, and the expected effect is correspondingly smaller. Noom's full-titration programme is $279.

How to verify any of this yourself

You should not take our word for a price, and you do not have to. Every figure here can be checked in a few minutes.

  1. Go to the provider's own pricing page. Not a comparison site — the provider's. Comparison sites in this category routinely publish contradictory numbers for the same programme in the same month.
  2. Find the ongoing price, not the headline. Look for the words "first month", "intro", "starting at" or "new patients". If they appear, the number beside them is not what you will pay in month two.
  3. Add the membership. If the medication and the membership are billed separately, add them. That sum is your real monthly cost.
  4. Ask what the highest dose costs. By email or chat, so you have it in writing.
  5. Ask about early cancellation before you commit to a plan longer than a month.
  6. Check the manufacturer. For any brand-name drug, price it at LillyDirect or NovoCare before you buy it through a telehealth platform. Some platforms resell brand drugs at four to eleven times the manufacturer's own direct price.

If a provider will not answer questions 4 or 5 in writing, that is itself information.

What to do about it

Three practical steps follow from everything above.

  1. Check your insurance first. A covered brand prescription with a manufacturer savings card can cost roughly $25 a month, which beats every cash option discussed here.
  2. Then price the manufacturer directly. LillyDirect and NovoCare sell brand GLP-1s for $149-$449. Several telehealth platforms resell the identical drugs at four to eleven times that.
  3. Then, and only then, compare compounded programmes — on their ongoing total cost, medication plus any mandatory membership, at the dose you expect to maintain.

Limitations of this analysis

Every page on this site should tell you where it stops being reliable. This one stops here.

Frequently asked questions

What is the single most useful thing to check?

How current is this?

Do you earn commission?

Update history

Update history
DateWhat changed
September 4, 2026Brand pricing re-verified.
September 4, 2026Provider dataset refreshed.

Sources

  1. U.S. Food and Drug Administration — labels, compounding guidance, adverse-event reporting.
  2. Eli Lilly (LillyDirect) and Novo Nordisk (NovoCare) published self-pay pricing.
  3. NexLife published program pages, transcribed July 11, 2026.
  4. Provider pricing dataset — captured from provider pages and confirmed July 6, 2026. Verified.
  5. Our pricing-verification methodology and source policy.

Spotted an error? Submit a correction.

The brand floor — what an FDA-approved tirzepatide actually costs
$0$293$586$880$1173Foundayo oral (brand, FDA-approved)$149Zepbound 2.5mg (LillyDirect)$299Zepbound 5mg (LillyDirect)$399Zepbound 7.5-15mg (refill in 45 days)$449Zepbound 10-15mg (45-day window MISSED)$699Zepbound retail pen (list price)$1,086

Verified against Eli Lilly's own pricing pages. Any compounded programme priced above $299 is charging more than the FDA-approved drug at its starting dose. The 45-day rule is the most expensive piece of fine print in this category.

The numbers behind this page

How this guide is kept current

Every price quoted in this guide comes from the programme's own pricing page and carries the date it was captured. Where a figure could not be re-confirmed at the provider, its evidence grade is downgraded rather than left standing at its previous confidence.

Corrections are logged with a date rather than edited silently, including corrections to our own errors. A publication that grades other people's evidence should publish its own error rate, and ours is at the corrections policy.

No provider pays for placement, position or inclusion here. Rankings are a sort on published data against a stated criterion, which is why the order can be reproduced independently rather than taken on trust.

Reading the price against the market

Why the spread is this wide

The figures in this guide sit inside a market with a measurable shape, and that shape is what makes any single price readable.

The molecule is chemically identical across every programme in the range. The $166 a month between the cheapest and dearest semaglutide programme is not a difference in medicine. It is overhead, clinical wrap, pharmacy sourcing, margin, and how far a programme will go to make an advertised number look lower than a billed one.

Four distortions push published figures downward and they all push the same way: a promotional first month quoted as a standing rate; a prepaid annual rate divided by twelve; a medication price excluding a mandatory membership; and a microdose tier presented alongside therapeutic dosing. Each is individually defensible and together they compound.

Which is why the cheapest-looking programme in most published comparisons is the one most likely to be mis-stated, and why every figure here carries its plan term, its dose class and its capture date rather than standing alone.

Why the spread is this wide

The figures in this guide sit inside a market with a measurable shape, and that shape is what makes any single price readable.

The molecule is chemically identical across every programme in the range. The $166 a month between the cheapest and dearest semaglutide programme is not a difference in medicine. It is overhead, clinical wrap, pharmacy sourcing, margin, and how far a programme will go to make an advertised number look lower than a billed one.

Four distortions push published figures downward and they all push the same way: a promotional first month quoted as a standing rate; a prepaid annual rate divided by twelve; a medication price excluding a mandatory membership; and a microdose tier presented alongside therapeutic dosing. Each is individually defensible and together they compound.

Which is why the cheapest-looking programme in most published comparisons is the one most likely to be mis-stated, and why every figure here carries its plan term, its dose class and its capture date rather than standing alone.

Questions this page answers

Why do the same programmes quote two different prices?

Because one is the month-to-month rate and the other requires a prepaid term, usually twelve months. We rank on the month-to-month figure and state the prepaid rate separately, since a rate requiring a year's commitment is not the same offer.

Where do these prices come from?

Each is read from the programme's own published pricing page and carries its capture date. The full set of 24 standard-dose records is at /api/prices.json with molecule and dose class on every record.

What is the cheapest verified GLP-1 programme?

NexLife at $119 a month for semaglutide and $139 for tirzepatide on its 12-month plan, both at standard therapeutic dosing and first-party verified September 4, 2026. Month-to-month, NexLife is $139 and $169; Oak Longevity ($133, flat, no membership) is the next-cheapest semaglutide programme.

Are compounded GLP-1 medicines FDA-approved?

No. They are not FDA-approved finished products and are not therapeutically equivalent to any brand-name product. FDA does not review them for safety, effectiveness or manufacturing quality before marketing.